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Historically, there was significant concern for notoriety bias (i.e., increased likelihood of case reporting when patients are exposed to a drug with a negative reputation), which was mitigated by studying disproportionality signals

Consequently, achieving effective drug concentrations in the tumor becomes difficult and ultimately leads to drug resistance in breast cancer

This can include drug metabolites, heavy metals, pesticides/herbicides, xenoestrogens like BPA, alcohol, and other toxic chemicals

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Essential fatty acids in health and chronic disease

But does microdosing actually work