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The aromatic amine Lip-1 is the foundation for the antioxidant activity of liproxstatin-1 analogs

Conference, US

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Abbreviations AD: Alzheimers disease ALA: -Linolenic acid ALS: Amyotrophic lateral sclerosis APP: Amyloid precursor protein ARA: Arachidonic acid A: Amyloid beta BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor COX-2: Cyclooxygenase 2 DHA: Docosahexaenoic acid EGCG: Epigallocatechin-3-gallate EPA: Eicosapentaenoic acid FOS: Fructooligosaccharides GC: Gas chromatography GPCRs: G-protein-coupled receptors IL: Interleukin iNOS: Inducible nitric oxide synthase LA: Linoleic acid LC: Liquid chromatography LPS: Lipopolysaccharide LTB: Leukotrienes B MAPK: Mitogen-activated protein kinase NADPH: Nicotinamide adenine dinucleotide phosphate NDD: Neurodegenerative diseases NEP: Neprilysin NF-B: Nuclear factor kappa B NMDAR: N-methyl D-aspartate receptor NOX-2: NADPH oxidase 2 Nrf2: Nuclear factor erythroid 2-related factor 2 PD: Parkinsons disease PGE2: Prostaglandin E PUFA: Polyunsaturated fatty acid ROS: Reactive oxygen species SCFA: Short-chain fatty acid SIRT1: Sirtuin-1 ThB: Thromboxane TLR-4: Toll-like receptor-4 TNF-: Tumor necrosis factor-alpha References Winter AN, Bickford PC

Stroke 47 , 28742876 (2016)

Although studies are scarce, here we discuss current knowledge on the underlying molecular pathways and provide a helpful review for further research and molecular targeting