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They function via a different, noncanonical method of Nrf2 activation

For instance, it has been associated with an increased risk of prostate cancer

The Human 48-Plex (#12007283M), plus soluble ICAM-1 (#171B6009M) and soluble VCAM-1 ((#171B6022M, all from Bio-Rad, Hercules, USA) were combined in one 50-Plex assay and serum samples were diluted 1 + 1 with sample diluent

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16 It should be noted that oxidative stress also plays a role in multiple chronic health conditions (e.g., diabetes, cancer, general aging, and cardiovascular, neuropsychiatric, and neurodegenerative diseases)