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Thus, a consequential constant leak of microbial entities sustains a persisting low-grade systemic inflammation system referred to as inflammaging

doi: 10.3389/fphys.2020.587674 10

Hypoxia (54) and HIF-1-mediated signaling (48) could induce the production of VEGF in TAM, suggesting that they could be a source of VEGF in the TME and could promote tumor angiogenesis