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It has been shown that modification of the C-3 position can effectively enhance the antiproliferative ability of caudatin against various cancer cell lines compared to the parent compound, presumably due to improved membrane permeability facilitated by increased lipophilicity (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) ( To summarize, the esterification and glycosylation of C-3 OH might be beneficial for improving bioactivity and lipid solubility

Clin Exp Pharmacol Physiol

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The Pfizer-BioNTech and Moderna boosters are considered equivalent, with no proven difference in terms of effectiveness or side effects for either one or for mixing vaccines