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This might be how augmented PPP comes into play: generating more NADPH or facilitating an NADPH/NADP + recycling while accumulating the building block R5P for DNA/RNA synthesis

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Then, cells were lysed in PBS, 1% Triton X-100 plus protease inhibitor cocktail (Thermo Fisher, A32955)

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(PubMed) Nakajima S, Iijima H, Egawa S, et al

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