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He R, Liu B, Xiong R, Geng B, Meng H, Lin W

Because the concentration of PQ in the brain following acute exposure is low, the possibility of neurotoxicity by PQ was overlooked in earlier studies as it was thought that the blood-brain barrier (BBB) would impede PQ entry into the brain

developed EGFR-targeted CRISPR-LNPs against PLK1 (sgPLK1-cLNPs) that led to selective uptake into disseminated ovarian cancer cells and facilitated up to 80% gene editing in vivo , significantly inhibiting tumor growth and improving survival by 80% in a mouse model (Rosenblum et al., 2020)

In metastatic or drug-resistant cancers, the regulatory control of c-MET is often compromised, resulting in oncogenic activation through either HGF-dependent or HGF-independent mechanisms

10.1016/j.plaphy.2013.11.027 33 RaisL.MasoodA.InamA.KhanN

In recent years, several plant-derived agents have gained attention for their anti-inflammatory, anti-oxidant, anti-proliferative, and immunomodulatory effects relevant to psoriasis treatment (Radu et al