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Modeling patient-derived glioblastoma with cerebral organoids

This is the first study to show profound nephroprotective effects of an SGLT2 inhibitor in patients with CKD and diabetes

and Kozlowska, L

Genetic ablation of arrestin 3 significantly reduces MOR uncoupling from G proteins upon chronic morphine treatment (Bohn et al., 2012)

AD is a disease of multifactorial origin characterized by (i) enhanced dysregulated redox metal (Cu, Fe)-catalyzed production of ROS and oxidative stress, (ii) the presence of abnormal structures, amyloid plaques (consisting of extracellular deposits of amyloid- (A) protein) and neurofibrillary tangles (abnormal accumulation of the protein tau), and (iii) acetylcholine deficiency caused by the disturbed (aberrant) activity of acetylcholinesterase