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In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging

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However, the poor fidelity to the in vivo conditions limits its efficacy, widening the translational gap between preclinical studies and clinical trials ( Hydrogel-based cell culture systems, spheroids and organoids, or their combination currently represent valid 3D cell culture models ( e.g

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In addition, NIE could be considered to have superior characteristics to NIB because NIE does not release NO in aqueous solutions, such as the blood

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