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However, by necessity 17-day-old mice were used (the gene-deficient animals die around day 21)

Another PI3K inhibitor LY294002 (20 M) had the similar results, indicating that PI3K contributes to IGF-1R mediated IA reduction[72]

Parisotto, R

The hydrogel-based drug delivery systems have emerged as a promising approach for targeted and sustained drug release due to their exceptional biocompatibility, adjustable physicochemical properties, and ability to encapsulate both hydrophilic and hydrophobic drugs [95]