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Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

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doi: 10.3389/fimmu.2025.1638352 Received 30 May 2025 Accepted 18 July 2025 Published 01 August 2025 Volume 16 - 2025 Edited by Michele Zanoni, Scientific Institute of Romagna for the Study and Treatment of Tumors (IRCCS), Italy Reviewed by Sourav Kumar Nandi, Jadavpur University, India Luo Qiang, Childrens Hospital of Chongqing Medical University, China Qihang Yuan, Dalian Medical University, China Updates Copyright 2025 Tong and Lou

Studies have shown that IL-1 and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation is crucial in inhibiting viral replication via maintenance of optimal interferon and immune response [34, 35]

(2020) N-Acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials