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10.1016/j.ejps.2017.10.024 75 SanoM.IchiharaG.KatsumataY.HiraideT.HiraiA.MomoiM

These are complementary rather than competing mechanisms

In the second reaction, glycine is attached to the C-terminal of -EC and this reaction is catalyzed by glutathione synthase (GSH2, EC 6.3.2.3) forming the tripeptide reduced glutathione (GSH) (Meister 1988) (Figure 4.1)