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Pathological astrocytes are distinguished by the expression of a specific marker WD Repeat Domain 49 (WDR49), while immunohistochemistry demonstrated that WDR49-positive astrocytes form clusters that are scattered randomly throughout the cortex of patients with FTD 225,226

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For further literature the reader is referred to more comprehensive reviews [276,277,278]

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10.1210/en.2003-1307 31 CourtiesA.GualilloO.BerenbaumF.SellamJ

Once the intracellular thioesterases cleave the acetyl group, this fresh supply of glutathione goes straight to work neutralizing the superoxide radicals and hydrogen peroxide that are damaging the cell