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Eur J Pharmacol 570:212221 Toda N, Toda H, Hatano Y (2007) Nitric oxide: involvement in the effects of anesthetic agents

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This can be attributed to local tissue hypoxia, bacterial colonisation of the wound, repetitive ischemia-reperfusion injury, and an altered cellular and systemic stress response in patients of older ages, all of which result in altered immune responses [41]

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