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Microbial systems, while advantageous for biopharmaceutical production, face challenges due to high-mannose N-glycosylation (Kulagina et al., 2021)

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Intriguingly, two other Tdf proteins are present in pathogenic but in none of the commensal Neisseria species, TdfF and TdfG (Marri et al., 2010), suggesting a key role in virulence

In fact, studies show that 85% of patients on 0.5 1.0 mg/kg/day achieve clear skin within 16 weeks, while 13% need 56 months of treatment and less than 1% may need to take the medication for up to 12 months 17

Chen CY, Davis E, White L, Patrick D