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Importantly, low aldosterone levels in combination with low ADH exacerbate extracellular volume contraction, impair baroreceptor-mediated compensation, and perpetuate hypovolemia and orthostatic intolerance

M1 macrophages rely on glycolysis to rapidly generate ATP and pro-inflammatory factors (e.g., IL-1, TNF-), while simultaneously producing large quantities of ROS

ACS Appl Nano Mater 1(6):26992708

These three pathophysiological pillars are intricately linked through a self-perpetuating redox-endocrine loop that amplifies metabolic and reproductive dysfunction

Epub 2016 Aug 22

Contribution of RhopH2 and RhopH3 to NPP The CLAG3 proteins are synthesized toward the end of the parasite asexual cell cycle, where they are stored in the rhoptry organelle in a complex, termed the RhopH complex, with two unrelated proteins named RhopH2 and RhopH3, which are encoded by single copy genes [( Plasmodium species, although the number of Clag genes varies among Plasmodium species