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doi: 10.1073/pnas.1316569111 57 ZurekG.KarstU

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Additionally, several other SNPs, including in CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase 1, involved in regulation of apoptosis), CYP2C8 (Cytochrome P450 Form 1) and CYP2C9 (Cytochrome P450 PB-1, both involved in hepatic drug clearance), NFATC2 (Nuclear Factor of Activated T-Cells 2), ID3 (Inhibitor Of Differentiation 3) and SLC10A2 (apical sodium-dependent bile acid transporter) have been suggested to be involved in vincristine-induced neuropathy (Johnson et al., 2011)

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The table below ( Table 2 ) indicates the urine volume to be excreted depending on the solute load and on urine osmolality