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GHK Cu is a synthetic coppertripeptide complex composed of glycyl L histidyl L lysine (GHK) chelated with copper(II), used in research to study tissue remodeling, extracellular matrix regulation, and copper dependent signaling in vitro and in animal models

This is not a controlled human dose-ranging trial

GHK-Cu was also shown to play a role in ischemic and diabetic wound healing in rats, as well as decreasing TNF-alpha levels and increasing collagen synthesis ( Anti-Inflammatory Effects of GHK-Cu As it was mentioned above, GHK-Cu is shown to have antioxidant and anti-inflammatory properties

Despite these benefits, some PPAR agonists, such as rosiglitazone and pioglitazone, have been associated with increased heart failure due to direct or indirect cardiac effects, such as fluid retention (3)

Oxidative stress, caused by elevated levels of ROS, can inhibit tumor growth by inducing cell death or suppressing proliferation [22]

However, the regulation of SIRT1 is tissue-specific and dose-dependent, and its long-term safety and targeted delivery strategies require further exploration