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We list it as our high-potency pick for two specific scenarios: anyone with documented deficiency working to replete liver stores, and anyone whose absorption is significantly compromised (long-term metformin + PPI combination, post-bariatric surgery, atrophic gastritis on biopsy)

Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes

I do always look at the positives, as having two of three brothers die in the last 11 months makes me see fighting for health is imperative and this is no where near as bad as my younger brother had...(Brain cancer)

Long-term systemic effects and interspecies variability are ongoing areas of investigation

In response to commenters' requests for clarification on whether the measure includes transfer patients, we clarify that transfer patients are included and assessed against all numerator criteria

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