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GHK appears to support remodeling and restructuring of connective tissue, modulating expression of numerous genes, including up-regulation of genes of the TGF- pathway

Studies where GHK was used for the healing of bone fractures in rats used a mixture of small molecules (Gly-His-Lys (0.5 g/kg), dalargin (1.2 g/kg) (an opioid-like synthetic drug), and the biological peptide thymogen (0.5 g/kg) (L-glutamyl-L-tryptophan)) to heal bones

Athletes should note that these compounds fall within categories prohibited by the World Anti-Doping Agency and are not permitted in tested competition.

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Areas with thinner skin, such as around the eyes or on the backs of hands, may show improvement earlier than areas with more significant laxity