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Moreover, PGD 2 is metabolized by 11-ketoreductase to 9,11-PGF 2 [109]

Besides their physiological and clinical relevance, crystallization of bacterial GGTs also unveiled molecular aspects of autoprocessing and catalysis, emphasizing the role of conserved threonine that acts as a nucleophile

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Immunohistochemical findings The caspase-3 immunoexpression was negative in the spiral ganglia in control (Fig

Chronic exposure to these drugs depletes presynaptic monoamine stores, impairs long-term neuronal signaling, and induces neurodegeneration ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

Inhibition of prostaglandin synthesis This 25-year-old woman presents with a long history of severe, cyclic pelvic pain occurring on the first day of menstruation