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For instance, TMAO, a metabolite produced by gut bacteria from dietary choline and carnitine, is closely associated with adverse cardiovascular outcomes when its plasma levels are elevated ( Shigella , can promote systemic inflammation, thereby increasing the risk of CVD ( Given the complex interactions between the gut microbiota and drugs, as well as the influence of the gut microbiota on CVD, the gut microbiota also plays a crucial role in shaping the therapeutic effects and side effects of cardiovascular drugs

doi: 10.1038/jcbfm.1993.48

Rosendahl AH, Hietala M, Henningson M, Olsson H, Jernstrm H

World 45 (6), 575582

The highly mutagenic and carcinogenic 10 S (+)- trans -BP- N 2 -dG adduct is the predominant steroisomer found in human cells treated with BP (~ 90%) 13 , and is more resistant to removal by the nucleotide excision repair (NER) pathway than the (+)- cis- adducts and ()- cis- adducts 14, 15

Additionally, GHK demonstrated the ability to reverse the expression of various genes, most notably, the gene signature of COPD