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To evaluate the effect of renal impairment on pudexacianinium PK, a separate ANCOVA for each renal impairment group (mild, moderate, and severe) was performed on natural logarithmic-transformed PK parameters (AUC inf , AUC last , and C max ) with renal function group as a fixed effect and age, sex, and BMI as candidate covariates

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doi: 10.3390/antiox11040673 197 SasaniniaKKelleyMAbnousianAOwensJYoonSYBeeverAet al

The rate of absorption depends on local perfusion at the site of intramuscular injection

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