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Transported toxins are usually processed by the liver

ALT is predominantly found in the liver, making it a more specific marker for liver damage

Of this 50%, 37% of DILI are associated with acetaminophen (APAP, paracetamol) and the other 13% are caused by isoniazid (isonicotinic acid hydrazide, INAH), TAA, erythromycin, diclofenac, and others [262]

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They may be utilized as induction or debulking therapy to lower the urate pool, followed by maintenance with urate-lowering therapy (ULT)

After 48 h, cells were washed with ice-cold PBS and lysed with 700 l of non-denaturing DISC lysis buffer (30 mM Tris-HCl (pH 7.4), 120 mM NaCl, 2 mM EDTA, 2 mM KCl, 1% Triton X-100, Roche complete protease inhibitor cocktail, 10 M PR619 and 1 mM NEM) on ice for 30 min