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[20] Patients should contact their GP or bariatric team promptly if they experience any of the following: New or worsening tingling, numbness, or weakness in the limbs Difficulty with balance, coordination, or memory Unexplained fatigue, breathlessness, or palpitations A sore or swollen tongue, or persistent mouth ulcers Any concern that they have missed supplementation for a prolonged period Symptoms that suggest anaemia, such as pallor or dizziness New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change warrant same-day assessment

Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness

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Developmental potential in the first 5 years for children in developing countries

While it is recommended to always follow the dosage recommendations, toxicity is not a concern when taking B12

These considerations matter when researchers aim to keep experimental conditions consistent and minimize variability in assay outputs