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19 HA creates volume and turgor of the skin through water attraction into the extracellular matrix, binding up to 1000 times its volume in water, to promote tissue hydration

Mitochondrial oxidative stress and dysfunction are the major cellular events associated with APAP-induced liver injury

Some of that tissue includes skin cells, which is part of the reason our skin becomes less flexible, less supple, and more wrinkly as we age

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[DOI] [PubMed] [Google Scholar] 206.Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, et al