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This metabolic alteration results in enhanced activation and differentiation of T-cells, culminating in the excessive production of pro-inflammatory cytokines, such as IFN- and TNF-

Low zinc levels have been correlated with depression, and zinc supplements have been shown to reduce symptoms of depression when used alone or with antidepressants

This platform was developed utilizing unbiased weighted gene co-expression network analysis (WGCNA) from PHH microarray data obtained from an open data repository, TG-GATES

222 UrichE.PatschC.AignerS.GrafM.IaconeR.FreskgrdP.-O

Chem Commun (Camb) 48 , 58355837, (2012)

The most commonly associated drugs are NSAIDs, diuretics and nalidix acid Acneiform (figure 9) Clinical features - tends to cause monomorphic papules and pustules without comedones Most commonly associated drugs - hormonal treatments (eg progestagens in contraceptive pills), steroids, lithium, phenytoin and isoniazid Always ask patients with very muscular physiques if they use anabolic steroids - patients may not come forward with this information at the first time of asking Fixed drug eruption (figures 10-15) Chronology - symptoms occur within 48 hours of commencing the medication Clinical features: Distribution - lips, face, distal limbs, hands & feet, glans penis and perianal skin