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Interestingly, according to transcriptome data generated by Sivaraman et al., hAAT OX primarily affects genes related to transcriptional regulation, while native hAAT affects genes involved in inflammatory pathways 68

2,3 Different cell death modes can be regulated by various signaling pathways

The deletion of gshA resulted in the lack of GSH and its intermediates, and cells with deleted gshB gene still produced -glutamylcysteine, which is an intermediate of GSH biosynthesis that exhibits antioxidant properties [11]

Endothelial cells absorb ferrous iron via the Tf-TFR1 pathway, and these endothelial cells in brain constitute the BBB [70], which tightly regulates the movement of ions and molecules

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The incidence of alveolar/bronchiolar adenomas was significantly higher in treated mice of both sexes than in controls (NCI, 1978)