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2.2.2 mRNA delivery RNA-based medicine has emerged as an alternative to DNA-based medicine due to technological breakthroughs such as the Nobel Prize winning development of nucleoside base modifications (111), which alongside other design features have endowed synthetic RNA constructs with greater stability and decreased immunogenicity (112)

After adjusting for MDS-UPDRS I score, indeterminate had a higher pupillomotor domain score than PIGD ( p = 0.05) and TD ( p = 0.004, Fig

Nuclear spin hyperpolarization Describes a nuclear spin polarization that goes far beyond the tiny equilibrium levels normally set by thermal energy in a magnetic field