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The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo

Additionally, ChaC2 E74Q/E83Q active site mutants exhibit a closed conformation, regulating the degradation activity of ChaC2 to GSH (20)

They serve as powerful signaling molecules, helping to regulate hormones, boost metabolism, stimulate healing, and enhance overall cellular function

convergence criteriamedium, no weighting

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In a chronic stress scenario, indeed, norepinephrine and cortisol overproduction can activate microglia and mast cell trough NLRP3 inflammasome, with release of pro-inflammatory cytokines, such as IL-1 and TNF-, and Reactive Oxygen Species (ROS) [55], causing neuroinflammation and depression [56]