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Defects in this gene result in familial adenomatous polyposis (FAP), an autosomal dominant precancerous condition that often progresses to malignancy

The depletion of GPX4 can increase the sensitivity of hepatocytes or cardiomyocytes to lipid peroxides, which can accelerate IRI-induced liver or cardiac injury [246,247,248]

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Notably, the NRF2 inhibitor Brusatol provides a compelling mechanistic example: it triggers ferroptosis in HNSCC models (including ESCC and OSCC) by promoting NRF2 degradation, which subsequently represses the expression of key genes like GCLC, thereby depleting GSH, enlarging the labile iron pool, and driving the accumulation of lethal lipid ROS (Zhu et al., 2023

How should researchers compare variants

C.ZhaoQ.et al (2016)