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Furthermore, studies using DSSinduced colitis models demonstrated significantly increased syn expression in the colon and notable syn deposits in the brain [132], supporting the hypothesis that the gastrointestinal tract serves as an initial site for syn pathology, which may then propagate to the CNS via the vagus nerve [23]

In addition, the inflammation impacts the kidneys and causes a reduced blood flow through the urinary system, which increases blood pressure in the body

An overview of Nrf2 signaling pathway and its role in inflammation

In many bacteria, the reactions of the -oxidation cycle can be carried out by multiple proteins (FadA to FadM), with FadE as the acyl-CoA dehydrogenase, FadB as the dual enoyl-CoA hydratase and 3-hydroxylacyl-CoA dehydrogenase, and FadA as the 3-ketoacyl-CoA thiolase (see Fig 1

Mol Cell Biol (2000) 20(14):5096106

Schweizer, U., Weitzel, J