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Therefore, a Phase I pharmacokineticpharmacodynamic bridging study is required to establish the relationship between steady-state plasma concentrations and analgesic thresholds in humans

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Experiments were performed at room temperature with glass pipettes (45 M resistance) filled with the intracellular solution comprising 140 mM KGluconate, 4 mM NaCl, 1 mM MgCl 2 , 1 mM EGTA, 5 mM HEPES, 2 mM MgATP, 0.6 mM NaGTP, pH = 7.4 (KOH)

This systemic inflammatory response can cross the BBB, exacerbating neuroinflammation and contributing to cognitive decline