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7,1214 Current guidelines for treatment of hypertension recommend starting monotherapy with any of the standard BP medication classes, including angiotensin-converting enzyme inhibitors, angiotensin II-receptor blockers, calcium-channel blockers, or diuretics in patients with uncomplicated hypertension

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The underlying molecular mechanisms involve direct ROS-induced oxidative damage to neuronal lipids, proteins and DNA [331], as well as ROS-mediated oxidative modifications that crucially promote the aberrant aggregation of toxic proteins [332]

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