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Dysfunctions in neurotransmitter signaling, affecting cholinergic and dopaminergic pathways in particular, have been involved in the occurrence of cognitive impairments

At pharmacologic doses (typically 5002000 mg daily), niacin has been used to modify lipid profiles, particularly raising high-density lipoprotein (HDL) cholesterol and lowering triglycerides and low-density lipoprotein (LDL) cholesterol

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Limit alcohol because it raises pancreatitis risk and can worsen low blood sugar