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(2021) employed tandem mass tag proteomics (TMT) and mass spectrometry (MS) to analyze PBMC, identifying differential expression of proteins regulated by the liver X receptor-retinoid X receptor (LXR/RXR) pathway, which modulates lipid metabolism and inflammation, potentially influencing the expression of pro-inflammatory cytokine genes (Schulman, 2017)

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Fluxomics The study of the flux or the change in the concentration of products and/or metabolites in a biosynthetic pathway in a cell as a function of time

We previously described that the verapamil stimulated GSH efflux mediated by MRP1 triggers cell death of Baby Hamster Kidney cells overexpressing MRP1 after transfection with the MRP1 gene and in human small cell lung cancer H69AR cells overexpressing MRP1 after doxorubicin selection 12,15