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Darkness, low light or shade mostly reduce the activity of GTs, while high light intensity elevates the activity and gene expression of GTs (Gall et al

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S7A-C).To determine whether blocking TDP-43 SUMOylation leads to phenotypes in an age-dependent manner, we assessed general wellness biweekly, including measuring body weight and hindlimb clasping scores, and performed a battery of 14 behavioral tests focusing on motor, social, and cognitive function related to ALS and FTD at three time points (2, 9 and 16 months, Fig