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This is especially relevant for individuals with a common genetic variation called MTHFR, which may affect an estimated 20 to 50 percent of the population

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After a median follow-up time of approximately 118 months, side effects of the MINE protocol were found to be mild and infrequent, and 5- and 10-year disease-free survival rates were both 65%

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[12] [13] Muscle biopsy can be useful if an episode of rhabdomyolysis is thought to be the result of an underlying muscle disorder