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However, the efficacy of these immunosuppressive treatments is not always consistent, and they can lead to significant adverse effects [132]

Short-term weight loss and hepatic triglyceride reduction: Evidence of a metabolic advantage with dietary carbohydrate restriction

The impact of sesquiterpenes -caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo

This toxic metal will further amplify lipid peroxidation through the Fenton reaction, eventually contributing to ferroptosis [203, 204]

Nonetheless, due to biological and physiological differences between a small animal model and humans, such as a thinner cartilage, possible spontaneous healing of defects, biomechanics, and physical loading in small animals, thus, an additional chondral defect repair study using minipigs should be conducted to confirm these effects