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For example, in hepatocellular carcinoma cells, the metabolic enzyme PCK1 (cytosolic phosphoenolpyruvate carboxykinase 1) is endowed with a nonmetabolic enzyme function, which promotes the activation of the SREBP (sterol regulatory element-binding proteins) signaling pathway and enhances lipid droplet synthesis in tumor cells [38]

Moreover, Tasi et al

In this review, we focus on mitochondrial dysfunction in the pathology of PD, outline the genes associated with familial PD and the factors related to sporadic PD, summarize current knowledge on the role of mitochondrial quality control of the disorder, and give an overview of therapeutic strategies for targeting mitochondria in neuroprotective interventions for PD

In vivo , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited a marked reduction in tyrosine hydroxylase (TH)-positive neurons and CD31 expression, along with significant decreases in GSH and GPX4 levels

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