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Suppression of Rac1 activity either by intragastric application of Rac1 inhibitor, Ehop-016, or by expression of dominant negative Rac1 rescued memory loss of APP/PS1 mice in water maze test, suggesting that increased Rac1 activity was responsible for the memory loss (Wu et al., 2019)

Complement activation, cytotoxicity, and alterations in cell junction proteins (e.g., reduced connexin-43) may also exacerbate tissue injury(Wroska et al., 2024)