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ICLs are essential for Mtb survival [147, 150], because the activity of ICLs increases dramatically as the cells reach the stationary phase [154], and when Mtb infects human inflammatory macrophages, its mRNA level also increases [155,156,157]

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Further, an improved molecular understanding of the precise cellular subsets and mechanisms underlying effective GVL as well as mechanisms of resistance to therapy will support development of rationally designed and more targeted therapies to sharpen the GVL effect of DLI while mitigating toxicities