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Extrinsic pathway The extrinsic pathway is primarily initiated by the interaction between cell death ligands and their receptors, leading to the formation of a death-inducing signaling complex (DISC), which subsequently activates caspase-8 and caspase-10 to trigger apoptosis [47]

[DOI] [PubMed] [Google Scholar] Rauckhorst A.J., Gray L.R., Sheldon R.D., Fu X., Pewa A.D., Feddersen C.R., Dupuy A.J., Gibson-Corley K.N., Cox J.E., Burgess S.C