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N.Y.2010Acad

167,336 Metabolic intermediates and by-products of the tricarboxylic acid cycle act as cofactors and substrates of various epigenetic enzymes, including acetyl CoA for acetylation and S-adenosylmethionine (SAM) for methylation

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The anterior cingulate cortex (ACC), which is pivotal for cognitive control, was selected as the regions of interest

This heterogeneity reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition puts a hard limit on all attempts to articulate an integrated perspective on bipolar disorder