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The mRNA levels of GCLC and GS were both lower (50% and 30%, respectively) while mRNA levels of GCLM were unchanged

This can result in the removal of an activation peptide and exposes a new N-terminus in the catalytic domain starting with Ile16

Chinese Society of Hepatology

The roles of lipid and glucose metabolism in modulation of -amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

219 Together with its upstream regulators and downstream effectors, mTORC1 plays a significant role in regulating mitochondrial fission and fusion (Fig