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Substantial evidence confirms that gut barrier dysfunction-induced microbial imbalance facilitates bacterial endotoxin (e.g., LPS) translocation across the intestinal epithelium into systemic circulation, precipitating metabolic endotoxemia - a process driving multi-tissue injury through systemic inflammatory responses (Saad et al., 2016)

Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

(Sparky House Publishing, 2014)

The root cause is insulin resistance

Arch Med Vet 46:299304

In the future, individual aging maps can be constructed by integrating multidimensional data such as blood metabolomics, gut microbiota metagenomics and epigenetic clocks