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albumin Alcohol use, gallstones, cholangitis, fatty liver (NASH), heart failure, and conditions requiring concomitant drugs can affect metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Hassan M.H., Desoky T., Sakhr H.M., Gabra R.H., Bakri A.H

Low levels trigger a cascade that ultimately leads to cell injury and death, which accelerates aging [17]

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As mentioned above, in mammalian mitochondria, it is believed that all or most of CI (90%) is associated with other complexes in SCs (54)