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Upon DNA damage, MRE11 is lactylated at K673, subsequently promoting its binding to DNA and facilitating DNA end resection and HR in cancer cells

National Organization for Rare Disorders

(b) Analysis by SDS-PAGE

doi: 10.1186/s40001-024-02176-w 24 FrhbeckG

Sermorelin is utilized as a selective agonist in studies of growth hormonereleasing hormone receptor (GHRHR)mediated signaling pathways

Abnormal drug tolerance Abnormal hormone secretion Abnormal movement Abnormality of secretion of gastrin Acanthosis nigricans Acneiform drug eruption Acneiform eruption Acquired acanthosis nigricans Acquired central hypothyroidism Acquired coagulation factor inhibitor disorder Acquired coagulation factor inhibitor disorder Acquired coagulation factor inhibitor disorder Acquired coagulation factor inhibitor disorder Acquired epidermolysis bullosa Acquired long QT syndrome Acquired thrombotic thrombocytopenic purpura Acute akathisia caused by drug Acute angle closure of left eye caused by drug Acute angle closure of left eye caused by drug Acute angle closure of right eye caused by drug Acute angle closure of right eye caused by drug Acute drug-induced gout Acute drug-induced interstitial lung disorder Acute drug-induced tubulointerstitial nephritis Acute drug-induced ulcer of stomach Acute drug-induced ulcer of stomach Acute edema Acute febrile neutrophilic dermatosis Acute gastric erosion associated with drug ingestion Acute gout Acute hepatic failure Acute hepatic failure due to drugs Acute pulmonary edema Acute toxic cicatrizing conjunctivitis Acute toxic conjunctivitis Acute tubulointerstitial nephritis Adverse cutaneous reaction to volatile oil Adverse drug interaction Adverse drug interaction Adverse drug interaction Adverse drug interaction Adverse drug interaction Adverse drug interaction Adverse drug interaction with dietary supplement Adverse drug interaction with herbal supplement Adverse drug interaction with over-the-counter medication Adverse drug interaction with prescription medication Adverse drug interaction with tobacco Adverse medication interaction with medication Adverse medication interaction with medication Adverse medication interaction with medication Adverse reaction caused by drug after provocation test Adverse reaction following injection of substance Adverse reaction following injection of substance Adverse reaction to biological substance Adverse reaction to drug Adverse reaction to lipotropic drugs Adverse reaction to oil Adverse reaction to pharmaceutical excipient Adverse reaction to substance applied to neonatal skin Akathisia Akathisia Akathisia caused by drug Allergic contact dermatitis caused by drug in contact with skin Allergic disorder monitoring status Allergic hepatitis Allergic reaction after allergen immunotherapy Allergic reaction after allergen immunotherapy Allergic reaction due to allergy skin test Allergic reaction to colophony Allergic reaction to drug Allergic sensitization Allergic sensitization by patch test Allergy drug side effect Anagen effluvium Anagen effluvium caused by drug Anaphylaxis after allergen immunotherapy Anastomotic ulcer of stomach caused by drug Androgen excess caused by drug Androgen level above reference range Anemia caused by medication Anetoderma Angle closure of left eye caused by drug Angle closure of left eye caused by drug Angle closure of left eye caused by drug Angle closure of left eye caused by drug Angle closure of left eye caused by drug Angle closure of right eye caused by drug Angle closure of right eye caused by drug Angle closure of right eye caused by drug Angle closure of right eye caused by drug Angle closure of right eye caused by drug Annular erythema Annular erythema caused by drug Aplasia cutis congenita due to teratogenic drug Aseptic meningitis caused by drug Aseptic peritonitis Atrophy of skin caused by drug Atrophy of skin caused by drug Atypical fracture of femur Autoimmune bullous dermatosis due to drug Autoimmune bullous dermatosis due to drug Autoimmune bullous dermatosis due to drug Autoimmune bullous dermatosis due to drug Autoimmune bullous dermatosis due to drug Autonomic neuropathy due to diabetes mellitus Autonomic neuropathy due to drug induced diabetes mellitus Autonomic neuropathy due to medication induced hypoglycemia Azoospermia caused by drug B cell lymphocyte aplasia caused by drug B-cell pseudolymphoma caused by drug Benign intracranial hypertension Benign intracranial hypertension due to drug Benign mucous membrane pemphigoid Benign mucous membrane pemphigoid with ocular involvement Bilateral acute angle closure Bilateral acute angle closure caused by drug Bilateral angle closure caused by drug Bilateral angle closure caused by drug Bilateral cataract of eyes caused by drug Bilateral keratopathy caused by drug Bilateral osteonecrosis of femurs caused by drug Bilateral secondary angle closure glaucoma Blistering of skin due to drug-induced coma Blistering of skin due to drug-induced coma Blood disorder monitoring status Blood drug side effect Bronchospasm Bronchospasm caused by drug Bullae and sweat gland necrosis in drug-induced coma Bullous dermatosis precipitated by drug treatment Bullous dermatosis precipitated by drug treatment Bullous dermatosis precipitated by drug treatment Bullous dermatosis precipitated by drug treatment Bullous dermatosis precipitated by drug treatment Bullous pemphigoid Capillaritis caused by drug Cardiomyopathy caused by drug Cataract due to diabetes mellitus Cataract due to drug induced diabetes mellitus Cataract of left eye caused by medication Cataract of left eye caused by medication Cataract of right eye caused by medication Cataract of right eye caused by medication Central hypothyroidism Central nervous system depression Cheilitis medicamentosa Chemical peritonitis Cholangiohepatitis Cholestatic hepatitis Cholestatic jaundice caused by drug Cholestatic jaundice syndrome Chorea due to tardive dyskinesia Chronic bilateral vestibulopathy caused by ototoxic agent Chronic cicatrizing conjunctivitis caused by drug Chronic disease - drug side effects Chronic drug-induced interstitial lung disorders Chronic drug-induced renal disease Chronic drug-induced tubulointerstitial nephritis Chronic drug-induced ulcer of stomach Chronic follicular conjunctivitis caused by drug Chronic gout caused by drug Chronic gout of ankle and/or foot without tophus caused by drug Chronic gout of elbow without tophus caused by drug Chronic gout of hand without tophus caused by drug Chronic gout of hip without tophus caused by drug Chronic gout of knee without tophus caused by drug Chronic gout of multiple sites without tophus caused by drug Chronic gout of shoulder without tophus caused by drug Chronic gout of vertebra without tophus caused by drug Chronic gout of wrist without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gout without tophus caused by drug Chronic gouty arthritis Chronic kidney disease stage 1 Chronic kidney disease stage 1 due to drug induced diabetes mellitus Chronic kidney disease stage 2 Chronic kidney disease stage 2 due to drug induced diabetes mellitus Chronic kidney disease stage 3 due to drug induced diabetes mellitus Chronic kidney disease stage 4 due to drug induced diabetes mellitus Chronic kidney disease stage 5 due to drug induced diabetes mellitus Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout caused by drug Chronic tophaceous gout of ankle and/or foot caused by drug Chronic tophaceous gout of elbow caused by drug Chronic tophaceous gout of hand Chronic tophaceous gout of hand caused by drug Chronic tophaceous gout of hip caused by drug Chronic tophaceous gout of knee caused by drug Chronic tophaceous gout of multiple sites caused by drug Chronic tophaceous gout of shoulder caused by drug Chronic tophaceous gout of vertebra caused by drug Chronic tophaceous gout of wrist caused by drug Chronic toxic cicatrizing conjunctivitis Chronic toxic interstitial nephritis Cicatrizing conjunctivitis Cicatrizing conjunctivitis Color changes during tooth formation Conjugated hyperbilirubinemia Conjunctival adrenochrome deposits Conjunctival deposit caused by drug Conjunctivitis caused by drug Conjunctivitis caused by drug Conjunctivitis caused by drug Conjunctivitis caused by drug Constricted pupil Constricted pupil Contact dermatitis caused by medication Cutaneous B-cell pseudolymphoma Cutaneous inflammation due to cytotoxic therapy Cutaneous T-cell pseudolymphoma Cutaneous ulceration due to cytotoxic therapy Cytopenia caused by drug Dermatosis due to cytotoxic therapy Dermatosis due to cytotoxic therapy Dermatosis due to cytotoxic therapy Dermatosis due to cytotoxic therapy Dermatosis due to cytotoxic therapy Diabetes mellitus induced by non-steroid drugs Diarrhea caused by drug Diffuse alopecia Dilated cardiomyopathy caused by drug Disorder of autonomic nervous system caused by drug Disorder of autonomic nervous system caused by drug Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of kidney due to drug induced diabetes mellitus Disorder of nail color Disorder of nail color Disorder of vision due to secondary diabetes mellitus Disturbance of hair cycle Disturbance of hair cycle Disturbance of salivary secretion Dizziness caused by drug Dizziness caused by drug Dose-related drug-induced neutropenia Drug exanthem Drug induced acquired central hypothyroidism Drug induced anal ulceration Drug induced central sleep apnea Drug induced dysfunction of vestibular system Drug induced lacrimal canalicular stenosis Drug induced pulmonary fibrosis Drug induced pulmonary fibrosis Drug induced thrombotic thrombocytopenic purpura Drug induction of cytochrome p450 CYP1A2 enzyme Drug induction of cytochrome p450 CYP2C19 enzyme Drug induction of cytochrome p450 CYP2C9 enzyme Drug induction of cytochrome p450 CYP3A enzyme Drug inhibition of cytochrome p450 CYP1A2 enzyme Drug inhibition of cytochrome p450 CYP2C19 enzyme Drug inhibition of cytochrome p450 CYP2C9 enzyme Drug inhibition of cytochrome p450 CYP2D6 enzyme Drug inhibition of cytochrome p450 CYP3A enzyme Drug interaction with drug Drug interaction with drug Drug interaction with drug Drug interaction with tobacco Drug interaction with tobacco Drug pigmentation Drug pigmentation Drug pigmentation Drug pigmentation Drug pigmentation Drug reaction AND/OR intoxication specific to newborn Drug reaction AND/OR intoxication specific to newborn Drug reaction with eosinophilia and systemic symptoms Drug related visual impairment Drug tolerance Drug-aggravated angioedema-urticaria Drug-exacerbated psoriasis Drug-induced acanthosis nigricans Drug-induced acute angle closure Drug-induced acute angle closure Drug-induced acute angle closure Drug-induced acute angle closure Drug-induced acute cicatrizing conjunctivitis Drug-induced acute dystonia Drug-induced acute pancreatitis Drug-induced acute pulmonary edema Drug-induced adrenocortical insufficiency Drug-induced adrenogenital disorder Drug-induced anaphylaxis Drug-induced androgenic alopecia Drug-induced anetoderma Drug-induced angioedema-urticaria Drug-induced angle closure Drug-induced angle closure glaucoma Drug-induced angle closure glaucoma Drug-induced angle closure glaucoma Drug-induced angle closure glaucoma Drug-induced angle closure glaucoma of bilateral eyes Drug-induced angle closure glaucoma of left eye Drug-induced angle closure glaucoma of left eye Drug-induced angle closure glaucoma of right eye Drug-induced angle closure glaucoma of right eye Drug-induced apnea Drug-induced apnea Drug-induced asthma Drug-induced autoimmune hemolytic anemia Drug-induced autoimmune reaction Drug-induced autonomic dysfunction Drug-induced bradycardia Drug-induced bradycardia Drug-induced bronchiolitis obliterans Drug-induced bullous pemphigoid Drug-induced cataract Drug-induced cataract Drug-induced cataract Drug-induced cataract Drug-induced central nervous system depression Drug-induced cerebellar ataxia Drug-induced cholestatic hepatitis Drug-induced chorea Drug-induced chronic hepatitis Drug-induced chronic pancreatitis Drug-induced cicatricial pemphigoid Drug-induced cirrhosis of liver Drug-induced coagulation inhibitor disorder Drug-induced coagulation inhibitor disorder Drug-induced coagulation inhibitor disorder Drug-induced colitis Drug-induced coma Drug-induced constipation Drug-induced corneal epithelial deposit Drug-induced cutis laxa Drug-induced dermatomyositis Drug-induced dermatosis Drug-induced desquamation of skin Drug-induced diabetes mellitus Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of cornea Drug-induced disorder of liver Drug-induced disorder of refraction AND/OR accommodation Drug-induced disorder of refraction AND/OR accommodation Drug-induced dyskinesia Drug-induced dyskinesia Drug-induced dyskinesia Drug-induced dyskinesia Drug-induced dyskinesia, acute onset Drug-induced dystonia Drug-induced dystonia Drug-induced dystonia Drug-induced dystonia Drug-induced embolism Drug-induced encephalopathy Drug-induced enteritis of intestine Drug-induced enteritis of intestine Drug-induced enzyme deficiency anemia Drug-induced eosinophilia Drug-induced epidermolysis bullosa acquisita Drug-induced epilepsy Drug-induced erythema multiforme Drug-induced erythromelalgia Drug-induced feminization Drug-induced fibrinolytic disorder Drug-induced flushing Drug-induced gingival hyperplasia Drug-induced granulomatous mediastinitis Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair abnormality Drug-induced hair color change Drug-induced hepatic necrosis Drug-induced hepatitis Drug-induced hepatitis Drug-induced hirsutism Drug-induced hypergastrinemia Drug-induced hyperglycemia Drug-induced hyperhidrosis Drug-induced hyperinsulinemia Drug-induced hyperkalemia Drug-induced hypermelanosis Drug-induced hypermelanosis Drug-induced hypermelanosis Drug-induced hyperprolactinemia Drug-induced hyperpyrexia Drug-induced hypersomnia Drug-induced hypertrichosis Drug-induced hypocalcemia Drug-induced hypoglycemia Drug-induced hypoglycemia without coma Drug-induced hypokalemia Drug-induced hypomagnesemia Drug-induced hypomelanosis Drug-induced hyponatremia Drug-induced hypoplasia of bone marrow Drug-induced hypotension Drug-induced ichthyosiform reaction Drug-induced ileus Drug-induced immune hemolytic anemia, hapten type Drug-induced immune hemolytic anemia, immune complex type Drug-induced immunodeficiency Drug-induced interstitial lung disorder Drug-induced interstitial lung disorder Drug-induced interstitial lung disorder Drug-induced interstitial lung disorder Drug-induced intrahepatic cholestasis Drug-induced keratoconjunctivitis Drug-induced lesion Drug-induced leukonychia Drug-induced linear IgA disease Drug-induced lupus erythematosus Drug-induced lymphocytic vasculitis Drug-induced male infertility Drug-induced megacolon Drug-induced melasma Drug-induced membranous nephropathy Drug-induced methemoglobinemia Drug-induced mucositis Drug-induced myasthenia Drug-induced myoclonus Drug-induced myopathy Drug-induced nail abnormality Drug-induced nail abnormality Drug-induced nail abnormality Drug-induced nail fragility Drug-induced nail hypertrophy Drug-induced necrotizing vasculitis Drug-induced neutropenia Drug-induced neutrophilia Drug-induced non autoimmune hemolytic anemia Drug-induced obesity Drug-induced ocular hypertension Drug-induced open angle glaucoma Drug-induced open angle glaucoma Drug-induced open angle glaucoma Drug-induced open angle glaucoma Drug-induced open angle glaucoma of bilateral eyes Drug-induced open angle glaucoma of left eye Drug-induced open angle glaucoma of left eye Drug-induced open angle glaucoma of right eye Drug-induced open angle glaucoma of right eye Drug-induced oral condition Drug-induced oral condition Drug-induced oral condition Drug-induced oral lichenoid reaction Drug-induced oral pigmentation Drug-induced oral ulceration Drug-induced orofacial dyskinesia Drug-induced osteoporosis Drug-induced osteoporosis Drug-induced osteoporosis with osteoporotic fracture Drug-induced palmoplantar pustular psoriasis Drug-induced panniculitis Drug-induced panniculitis Drug-induced pemphigus Drug-induced pemphigus foliaceus Drug-induced pemphigus vulgaris Drug-induced peptic ulcer Drug-induced pericarditis Drug-induced persistent light reaction Drug-induced pigmentation Drug-induced pigmentation Drug-induced pigmentation Drug-induced pigmentation Drug-induced pigmentation Drug-induced pigmentation Drug-induced pigmentation of cornea Drug-induced pleural effusion Drug-induced pleurisy Drug-induced pneumonitis Drug-induced polymyositis Drug-induced porphyria Drug-induced pseudoporphyria Drug-induced pseudoscleroderma Drug-induced pseudoxanthoma elasticum Drug-induced purpura Drug-induced purpura Drug-induced purpura Drug-induced Raynaud's phenomenon Drug-induced retinopathy Drug-induced sideroblastic anemia Drug-induced solar urticaria Drug-induced Stevens-Johnson syndrome Drug-induced stricture of esophagus Drug-induced systemic lupus erythematosus Drug-induced tardive dystonia Drug-induced telangiectasia Drug-induced thyroiditis Drug-induced tubulointerstitial nephritis Drug-induced ulceration Drug-induced uveitis Drug-induced virilization Drug-induced xerostomia Drug-related alopecia Drug-related myocardial necrosis syndrome Duodenal ulcer caused by drug Duodenitis caused by drug Dysfunction of vestibular system Dysmotility of small intestine caused by drug Effect of drug maladministration Effects of immunotherapy Emollient adverse reaction End stage renal disease on dialysis due to drug induced diabetes mellitus End stage renal failure on dialysis Endocrine alopecia Endocrine drug side effect Enlargement of alveolar ridge ENT disorder monitoring status ENT drug side effect Epidermal fragility Eruption caused by drug Erythema nodosum caused by drug Erythroderma caused by drug Erythromelalgia Esophagitis medicamentosa Exanthematous disorder Excessive muscarinic activity Exogenous pigmentation of oral mucosa Extrinsic staining of teeth caused by drug Factor IX inhibitor disorder Factor V inhibitor disorder Factor VIII inhibitor disorder Falls Falls caused by medication Fat hypertrophy Fat hypertrophy due to injection of drug or medicament Feminization Fixed drug eruption Fixed drug reaction Fixed drug reaction Fixed drug reaction Fixed drug reaction affecting oral mucous membranes Folate deficiency anemia, drug-induced Gastric erosion Gastric ulcer caused by drug Gastric ulcer caused by drug Gastric ulcer caused by drug Gastric ulcer caused by drug Gastritis medicamentosa Gastritis medicamentosa Gastroenteritis caused by drug Gastrointestinal disorder caused by drug Generalized enamel hypoplasia associated with ingestion of drugs Generalized rash Generalized skin eruption caused by drug and medicament Gingival disease caused by drug Gingival disease caused by drug Gingival disease caused by drug Gingival disease caused by drug Gingival enlargement exacerbated by drug Gingivitis caused by drug Gout of ankle and/or foot caused by drug Gout of ankle and/or foot caused by drug Gout of ankle and/or foot caused by drug Gout of elbow caused by drug Gout of elbow caused by drug Gout of elbow caused by drug Gout of hand caused by drug Gout of hand caused by drug Gout of hand caused by drug Gout of hip caused by drug Gout of hip caused by drug Gout of hip caused by drug Gout of knee caused by drug Gout of knee caused by drug Gout of knee caused by drug Gout of multiple sites caused by drug Gout of multiple sites caused by drug Gout of shoulder caused by drug Gout of shoulder caused by drug Gout of shoulder caused by drug Gout of vertebra caused by drug Gout of vertebra caused by drug Gout of vertebra caused by drug Gout of wrist caused by drug Gout of wrist caused by drug Gout of wrist caused by drug Gout secondary to drug Granulomatous mediastinitis Gray syndrome from chloramphenicol administration in newborn Gyne