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The negative results of the latter study may, at least partly, be due to the large heterogeneity of causes of AKI (trauma, hypertension, surgery, drugs or sepsis) and/or the delayed initiation of rhIGF-1 treatment, i.e., after established AKI

J Clin Invest 2000, 105 (8), 10671075

CNS and Neurological Disorders-Drug Targets, 17 (8), 590594

Preclinical studies have evaluated KD primarily in SOD1 transgenic mouse models, which exhibit progressive motor neuron degeneration, muscle weakness, and mitochondrial dysfunction, thereby recapitulating key features of disease progression [40, 102]

Theoretical concerns worth understanding: The biggest theoretical concern with any telomerase activator is the possibility of accelerating tumor growth in undiagnosed early-stage cancers

Furthermore, findings of aberrant intra-network homogeneity involving the DMN of bipolar patients, was also reproduced (94)