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Given the essential role of astrocytes in clearing and detoxifying many substances and the changes in astrocyte functions that such substances can evoke, it is interesting to consider (and worthy of more extensive investigation) that chronic exposure to trace amounts of such substances might act as risk factors and comorbidities in a variety of CNS neurodegenerative conditions

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Dopamine also functions as a paracrine (cell-to-cell) hormone in other parts of the body

DSM-III: Diagnostic and Statistical Manual of Mental DisordersIII